College Football Odds Week 12: Spreads, Lines, Trends for Every Top 25 Game

College Football Odds Week 12

College football odds for Week 12 have a dearth of ranked team-vs.-ranked team matchups, but there are a few. Most notably, No. 1 Georgia travels to No. 21 Tennessee, and No. 5 Washington visits No. 10 Oregon State.

Here’s everything you need to know about the college football odds Week 12 market: opening lines, spreads and betting trends for every game, as multiple oddsmakers provide insights on college football Week 12 odds and action. Check back regularly for updates and use our new ESPN BET promo code to get the most out of your action when the new sportsbook launches Tuesday.

College Football Odds for Week 12

No. 3 Michigan vs Maryland Odds

• Opening point spread: Michigan -20.5
• Opening moneyline: Michigan -1300/Maryland +800
• Opening total: Over/Under 51 points scored
• Time: Noon ET Saturday (FOX)

UPDATE 2 P.M. ET MONDAY: Michigan (10-0 SU/5-4-1 ATS) didn't have coach Jim Harbaugh on the sidelines against Penn State. It might have mattered a little, but the Wolverines used a ground-and-pound game and defense to claim a 24-15 victory as 4.5-point road faves.

Maryland (6-4 SU/4-6 ATS) snapped an 0-4 SU and ATS slide in Week 11. The Terrapins edged Nebraska 13-10 and narrowly cashed laying 2 points on the road.

TwinSpires has already dipped a point on Michigan, moving to -20, then-19.5. The Wolverines are seeing 65% of early spread tickets, while 54% of early spread cash is on the Terrapins.

"Sharp play on Maryland +20.5," Lucas said.

The total ticked from 51 to 50.5, with 56% of tickets/64% of dollars on the Under.

No. 10 Louisville vs Miami Odds

• Opening point spread: Louisville -1.5
• Opening moneyline: Louisville -115/Miami -106
• Opening total: Over/Under 47points scored
• Time: Noon ET Saturday (ABC)

UPDATE 2 P.M. ET MONDAY: Louisville (9-1 SU/5-4-1 ATS) held a 14-0 halftime lead over Virginia, then gave it all back and then some in the third quarter. The Cards trailed 21-14 entering the fourth quarter, but rallied for a 31-24 victory.

Still, Louisville fell far short of covering as 20.5-point chalk.

Meanwhile, Miami's 4-0 SU start – which would've been 5-0 if not for a historically dumb coaching decision vs. Georgia Tech – is now a distant memory. The Hurricanes are 2-4 SU and ATS in their last six games to stand 6-4 SU/5-5 ATS on the season.

In Week 11, Miami hung around at unbeaten Florida State, but didn't have enough in a 27-20 loss getting 14.5 points.

TwinSpires Sportsbook opened Louisville -1.5 vs. Miami, and the number is up to -2 in the college football Week 12 odds market. The Cardinals are getting 60% of early spread bets/69% of early spread money.

"It's a mix of sharp and public play on Louisville. We're going to need Miami, with all of the Louisville handle we see each week," TwinSpires director of retail sports Zachary Lucas said.

Indeed, TwinSpires has a big footprint in Kentucky and draws plenty of Cardinals and Kentucky Wildcats action.

The total bumped from 47 to 47.5 in the early going, with 57% of tickets/58% of money on the Over.

No. 14 Oklahoma vs BYU Odds

• Opening point spread: Oklahoma -24
• Opening moneyline: Oklahoma -2800/BYU +1250
• Opening total: Over/Under 57 points scored
• Time: Noon ET Saturday (ESPN)

UPDATE 2 P.M. ET MONDAY: After dropping two in a row to likely blow up its CFP chances, Oklahoma took out its frustrations on West Virginia. The Sooners (8-2 SU/7-3 ATS) hammered the Mountaineers 59-20 giving 13 points at home.

BYU (5-5 SU/3-7 ATS) is on an 0-3 SU and ATS skid entering Week 12. The Cougars got drummed by Iowa State in Week 11, losing 45-13 as 7.5-point home underdogs.

Caesars Sports hasn't moved off its Oklahoma-BYU opener of Sooners -24.

Rutgers vs No. 12 Penn State Odds

• Opening point spread: Penn State -19
• Opening moneyline: Penn State -1400/Rutgers +800
• Opening total: Over/Under 43.5 points scored
• Time: Noon ET Saturday (FS1)

UPDATE 2 P.M. ET MONDAY: Penn State (8-2 SU/7-3 ATS) likely saw its Big Ten championship game hopes – and therefore any CFP hopes – go up in smoke against Michigan. The Nittany Lions hung around the whole game, but couldn't get enough offense in a 24-15 loss as 4.5-point home underdogs.

Rutgers (6-4 SU/6-2-2 ATS) got shut out at Iowa, losing 22-0 as a 1.5-point road pup.

Rutgers-Penn State opened at Nittany Lions -19 Sunday afternoon at Caesars, and the line climbed to 19.5/20.5 this morning. Conversely, the total is down 1.5 points to 42.

No. 24 Tulane vs Florida Atlantic Odds

• Opening point spread: Tulane -9
• Opening moneyline: Tulane -360/Florida Atlantic +290
• Opening total: Over/Under 48 points scored
• Time: Noon ET Saturday (ESPN+)

UPDATE 2 P.M. ET MONDAY: Tulane (10-0 SU/3-7 ATS) remained unbeaten with yet another squeaker of a win as a heavy favorite. The Green Wave, laying 24.5 vs. visiting Tulsa, held on for a 24-22 victory.

Tulane's last three wins have come by a combined 7 points, with the Green Wave double-digit faves in all three games. Tulane is on a 1-6 ATS purge.

Florida Atlantic (4-6 SU and ATS) closed as a 7.5-point home favorite against East Carolina and got dusted outright 22-7.

Caesars Sports moved Tulane from -9 to -9.5 today. The total initially nudged up to 48.5, but it's now down to 47.5.

Chattanooga vs No. 8 Alabama Odds

• Opening point spread: TBA
• Opening moneyline: Alabama TBA/Chattanooga TBA
• Opening total: Over/Under TBA
• Time: Noon ET Saturday (ESPN+)

UPDATE 2 P.M. ET MONDAY: Since a Week 2 upset home loss to Texas, Alabama is 8-0 SU/6-2 ATS. In Week 11, the Crimson Tide went to Kentucky as 10.5-point favorites and exited with a 49-21 blowout win.

After facing seven straight SEC foes – including wins over ranked Ole Miss, Tennessee and LSU teams – 'Bama (9-1 SU/7-3 ATS) gets a break this week against FCS outfit Chattanooga.

The Mocs (7-3 SU) are having a decent season in the Southern Conference and are coming off a bye. In Week 10, Chattanooga fell to Furman 17-14.

Louisiana-Monroe vs No. 13 Mississippi Odds

• Opening point spread: Mississippi -36
• Opening moneyline: Ole Miss TBA/ULM TBA
• Opening total: Over/Under 62.5 points scored
• Time: Noon ET Saturday (SEC Network)

UPDATE 2 P.M. ET MONDAY: Ole Miss had a chance to gain new respect and some consideration in College Football Playoff odds. But alas, the Rebels were no match for two-time defending national champion Georgia.

Mississippi (8-2 SU/6-3-1 ATS) took a 52-17 beating as an 11.5-point road 'dog.

The Rebels will likely have no trouble rebounding against Sun Belt foe Louisiana-Monroe (2-8 SU/4-6 ATS). In Week 11, the Warhawks got drubbed by Troy 45-14 catching 21.5 points at home.

Ole Miss moved from -36 to -36.5 this morning at Caesars Sports.

Appalachian State vs No. 18 James Madison Odds

• Opening point spread: James Madison -12
• Opening moneyline: James Madison -450/Appalachian State +350
• Opening total: Over/Under 55.5 points scored
• Time: 2 p.m. ET Saturday (ESPN+)

UPDATE 2:30 P.M. ET MONDAY: James Madison (10-0 SU/7-3 ATS) thumped UConn 44-6 laying 25.5 points at home in Week 11. Appalachian State (6-4 SU/4-5-1 ATS) rolled over Georgia State 42-14 catching 3 points on the road.

The undefeated Dukes opened -12 on Caesars' college football Week 12 odds board. James Madison got bet down to -11 this morning and is now -11.5.

James Madison isn't ranked in the CFP poll, since it's in the second year of the two-year transition from FCS to FBS and therefore isn't eligible to play in a bowl game. But the Dukes are No. 18 in the AP poll.

So we're keeping JMU's games in this report, because we're not going to honor the NCAA's shortsightedness. The university is in the midst of its second appeal to the NCAA to reduce the transition to one year.

No. 22 Utah vs No. 17 Arizona Odds

• Opening point spread: Arizona -1
• Opening moneyline: Arizona -110/Utah -110
• Opening total: Over/Under 45 points scored
• Time: 2:30 p.m. ET Saturday (Pac-12 Network)

UPDATE 2 P.M. ET MONDAY: Utah gave unbeaten Washington all it could handle, leading 28-24 well into the fourth quarter. But the Utes (7-3 SU/6-3-1 ATS) couldn't hold off Michael Penix and Co., losing 35-28 while covering as 9.5-point road pups.

Arizona enters on a four-game SU win streak (3-1 ATS). In Week 11 at Colorado, the Wildcats survived a back-and-forth battle, winning 34-31 on a final-seconds field goal. But the 'Cats fell short of cashing as 8-point favorites.

The Utah-Arizona spread has already jumped the fence at TwinSpires, from Arizona -1 to Utah -1. The Utes are drawing 62% of spread bets/66% of spread dollars.

"Early money is on the Utes," Lucas said.

The total moved from 45 to 44.5 early, with 60% of bets on the Over/56% of money on the Under.

"Sharp play on Under 45," Lucas said.

No. 1 Georgia vs No. 18 Tennessee Odds

• Opening point spread: Georgia -10
• Opening moneyline: Georgia -365/Tennessee +265
• Opening total: Over/Under 59.5 points scored
• Time: 3:30 p.m. ET Saturday (CBS)

UPDATE 2 P.M. ET MONDAY: Georgia (10-0 SU/4-6 ATS) made a strong case to overtake Ohio State atop the CFP rankings. Facing No. 9 Ole Miss, the Bulldogs bulldozed to a 52-17 home win giving 11.5 points.

Georgia remains No. 1 in the AP poll.

Tennessee (7-3 SU/6-4 ATS) closed as a 2.5-point favorite at Missouri and took an early 7-3 lead. But the Vols didn't score again, giving up 33 straight points in a 36-7 loss.

Georgia is already up a half-point to -10.5 in TwinSpires' college football odds Week 12 market. Ticket count is 2/1 and money 3/1 on the Bulldogs.

"We're seeing early lopsided money on Georgia. It's very likely the Vols will be a big need for us," Lucas said.

The total nudged from 59.5 to 59, with 52% of early tickets/59% of early money on the Under.

No. 20 North Carolina vs Clemson Odds

• Opening point spread: Clemson -7.5
• Opening moneyline: North Carolina -267/Clemson +215
• Opening total: Over/Under 58 points scored
• Time: 3:30 p.m. ET Saturday (ESPN)

UPDATE 2 P.M. ET MONDAY: North Carolina (8-2 SU/6-4 ATS) survived a wild shootout against rival Duke in Week 11. The Tar Heels got a field goal as time expired to tie the game at 36 and force overtime. UNC went on to win 47-45 in double overtime, but didn't cover as 10.5-point chalk.

Clemson (6-4 SU/4-6 ATS) is trying to salvage a disappointing season. In Week 11, the Tigers gave up a first-quarter TD to Georgia Tech to fall behind 7-0. But Dabo Swinney's squad scored the next 42 points in a 42-21 home rout laying 14.5 points.

Clemson actually opened -7.5 at Caesars, and that number is already down to -6.5, with a stop at -7 along the way.

Wake Forest vs No. 19 Notre Dame Odds

• Opening point spread: Notre Dame -24.5
• Opening moneyline: Notre Dame -4000/Wake Forest +1450
• Opening total: Over/Under 47 points scored
• Time: 3:30 p.m. ET Saturday (NBC)

UPDATE 2 P.M. ET MONDAY: Notre Dame (7-3 SU and ATS) had a bye in Week 11, and probably needed it. In Week 10, the Fighting Irish fell to Clemson 31-23 giving 3 points on the road.

Wake Forest (4-6 SU and ATS) lost to North Carolina State 26-6 as a 1.5-point home underdog. After winning their first three games, the Demon Deacons are on a 1-6 SU skid (3-4 ATS).

Notre Dame remains at Caesars' -24.5 opener, and the total is up a notch to 47.5.

Illinois vs No. 16 Iowa Odds

• Opening point spread: Iowa -4
• Opening moneyline: Iowa -178/Illinois +150
• Opening total: Over/Under 30 points scored
• Time: 3:30 p.m. ET Saturday (FS1)

UPDATE 2 P.M. ET MONDAY: Iowa's ability to win ugly, low-scoring games is unparalleled in college football. The Hawkeyes (8-2 SU/5-4-1 ATS) have seen the Over hit in just one of their last six games, and they've gone 5-1 SU in that span (3-2-1 ATS).

In Week 11, Iowa was up 6-0 going into the fourth quarter of a rock fight vs. Rutgers. Then the Hawkeyes exploded – particularly by their standards – for two TDs and a field goal to win 22-0 as 1.5-point home faves.

The Under is on a 5-0 run for Iowa, and the 22-point barrier hasn't been surpassed in its last four games.

By comparison, Illinois' Week 10 contest with Indiana was a complete 180. The Illini (5-5 SU/2-8 ATS), 5-point home favorites, won a scoring festival 48-45 in overtime.

Iowa slipped from -4 to -3.5 this morning at Caesars Sports. And the tidy total of 30 actually ticked up to 30.5.

Minnesota vs No. 2 Ohio State Odds

• Opening point spread: Ohio State -28.5
• Opening moneyline: Ohio State -4500/Minnesota +1550
• Opening total: Over/Under 49 points scored
• Time: 4 p.m. ET Saturday (Big Ten Network)

UPDATE 2 P.M. ET MONDAY: Ohio State (10-0 SU/5-4-1 ATS) hopes to maintain its spot atop the CFP rankings. In Week 11, the Buckeyes led Michigan State 35-3 at halftime and let off the gas from there, winning 38-3 as 32.5-point home favorites.

Minnesota (5-5 SU/3-7 ATS) was a modest 1.5-point fave at Purdue and got blown out 49-20.

Caesars moved Ohio State from -28.5 to -27.5 this morning.

No. 6 Oregon vs Arizona State Odds

• Opening point spread: Oregon -22.5
• Opening moneyline: Oregon -1700/Arizona State +950
• Opening total: Over/Under 54 points scored
• Time: 4 p.m. ET Saturday (FOX)

UPDATE 2 P.M. ET MONDAY: Oregon (9-1 SU/8-1-1 ATS) stayed firmly in the College Football Playoff odds conversation in Week 11. The Ducks topped Southern Cal 36-27, but didn't cover as 16.5-point home favorites.

Arizona State (3-7 SU/5-4-1 ATS) notched a surprising Week 11 victory. The Sun Devils closed as 14.5-point road 'dogs and beat UCLA 17-7.

Neither the spread nor total have moved early on in Caesars' college football odds Week 12 market.

No. 23 Oklahoma State vs Houston Odds

• Opening point spread: Oklahoma State -7.5
• Opening moneyline: Oklahoma State -292/Houston +235
• Opening total: Over/Under 60 points scored
• Time: 4 p.m. ET Saturday (ESPN2)

UPDATE 2 P.M. ET MONDAY: Oklahoma State's five-game SU and ATS run crashed in blowout fashion. The Cowboys (7-3 SU/6-4 ATS) were 2.5-point favorites at Central Florida and got trucked 45-3.

Houston (4-6 SU/5-5 ATS) also fell short as a Week 11 favorite. The Cougars lost to Cincinnati 24-14 giving 3 points at home.

Caesars opened Oklahoma State-Houston at Cowboys -7.5 and dipped to -7 this morning. The total is also down a half-point to 59.5.

North Alabama vs No. 4 Florida State Odds

• Opening point spread: TBA
• Opening moneyline: Florida State TBA/North Alabama TBA
• Opening total: Over/Under TBA
• Time: 6:30 p.m. ET Saturday (CW Network)

UPDATE 2 P.M. ET MONDAY: Florida State (10-0 SU/6-4 ATS) got a good test from Miami in Week 10. The game was tied at 10 at halftime, and the Seminoles trailed 13-10 early in the third quarter.

But the 'Noles then strung together three straight scores – a field goal and two TDs – and held on for a 27-20 win as 14.5-point home favorites.

Up next for Florida State is practically a bye against FCS foe North Alabama (3-7 SU). The Lions were off in Week 11, after a 27-14 home loss to Central Arkansas in Week 10.

No. 21 Kansas State vs No. 25 Kansas Odds

• Opening point spread: Kansas State -7.5
• Opening moneyline: Kansas State -315/Kansas +245
• Opening total: Over/Under 55.5 points scored
• Time: 7 p.m. ET Saturday (FS1)

UPDATE 2 P.M. ET MONDAY: Kansas State (7-3 SU/7-2-1 ATS) is a missed fourth-and-goal away from being on a five-game SU and ATS win streak. Still, the Wildcats are 4-1 SU/4-0-1 ATS in their last five.

In Week 11, K-State put a 59-25 beatdown on Baylor laying 21 points at home.

On the flip side, Kansas (7-3 SU/5-5 ATS) lost to Texas Tech 16-13 giving 3.5 points at home.

Kansas State opened and remains -7.5 on TwinSpires' college football Week 12 odds board. Home underdog Kansas is taking 76% of early spread bets/77% of early spread money.

"Kansas is the clear trendy 'dog of the week. Kansas moneyline is also a big liability already, with 4/1 tickets and 6/1 money on the Jayhawks," Lucas said.

The total is stable at 55.5, with 63% of bets/69% of cash on the Over.

No. 5 Washington vs No. 11 Oregon State Odds

• Opening point spread: Oregon State -1
• Opening moneyline: Oregon State -113/Washington -108
• Opening total: Over/Under 64 points scored
• Time: 7:30 p.m. ET Saturday (ABC)

UPDATE 2 P.M. ET MONDAY: Washington (10-0 SU/5-4-1 ATS) kept its CFP hopes quite alive with a big finish against a solid Utah outfit. Trailing 28-24 well into the fourth quarter, the Huskies scored the final 11 points to win 35-28. But Washington failed to cash as 9.5-point home chalk.

Oregon State (8-2 SU/6-4 ATS) had no such troubles with Stanford. The Beavers rumbled to a 62-17 home win, easily covering as 21.5-point faves.

Perhaps surprisingly, Oregon State opened as a 1-point home favorite against unbeaten Washington. The number hasn't moved yet at TwinSpires, though early tickets and money are running 2/1 on the Huskies.

"A 10-0 team at nearly a pick 'em is tough to pass up. I expect the public to be all over Washington this week," Lucas said.

The total moved from 64 to 64.5, with tickets and money just shy of 2/1 on the Over.

Florida vs No. 9 Missouri Odds

• Opening point spread: Missouri -11
• Opening moneyline: Missouri -440/Florida +335
• Opening total: Over/Under 59.5 points scored
• Time: 7:30 p.m. ET Saturday (ESPN)

UPDATE 2 P.M. ET MONDAY: Missouri (8-2 SU/7-3 ATS) apparently took umbrage with being a 2.5-point home 'dog against Tennessee. The Tigers boat-raced the Vols 36-7, shutting out Tennessee over the final 57 minutes-plus.

Mizzou has covered four in a row and is 7-1 ATS in its last eight games.

Meanwhile, Florida (5-5 SU/3-7 ATS) is just hoping to get bowl-eligible. In Week 11, the Gators pressed LSU into the fourth quarter, trailing 38-35 with 10:27 remaining. But Florida couldn't keep handle Jayden Daniels, losing 52-35 as a 16.5-point road pup.

The Gators are on an 0-3 SU and ATS slide.

This morning, Missouri moved from -11 to -11.5 on Caesars Sports' college football Week 12 odds board.

No. 7 Texas vs Iowa State Odds

• Opening point spread: Texas -9
• Opening moneyline: Texas -375/Iowa State +285
• Opening total: Over/Under 48 points scored
• Time: 8 p.m. ET Saturday (FOX)

UPDATE 2 P.M. ET MONDAY: Texas (9-1 SU/4-6 ATS) was on cruise control at halftime against TCU, holding a 26-6 lead. Ultimately, the Lonhorns barely held on for a 29-26 Week 11 victory, failing to cash as 13-point road favorites.

Iowa State (6-4 SU and ATS) went to BYU as a 7.5-point favorite and exited with a blowout 45-13 victory. The Cyclones are 4-1 SU and ATS in their last five games.

Texas is already down a point to -8 in TwinSpires' college football odds Week 12 market. The Longhorns are netting 58% of early spread tickets, but 60% of early spread cash is on the Cyclones.

"It's shaping up to be a Pros vs. Joes battle. The pros are on Iowa State," Lucas said.

The total inched from 48 to 48.5, with tickets and money in the 2/1 range on the Over.

Georgia State vs No. 15 LSU Odds

• Opening point spread: LSU -31.5
• Opening moneyline: LSU -25000/Georgia State +2500
• Opening total: Over/Under 71.5 points scored
• Time: 8 p.m. ET Saturday (ESPN2)

UPDATE 2 P.M. ET MONDAY: The Jayden Daniels Heisman Trophy campaign was on full display when LSU met Florida in Week 11. Daniels threw for 372 yards and three TDs, and he rushed for a whopping 234 yards and another two TDs.

LSU (7-3 SU/6-4 ATS) needed all that effort to pull away late for a 52-35 win laying 16.5 points at home.

After a solid 6-1 SU/5-2 ATS start, Georgia State is on an 0-3 SU and ATS purge. In Week 11, the Panthers (6-4 SU/5-5 ATS) were 3-point home favorites vs. Appalachian State and got plowed under 42-14.

Caesars Sports opened Georgia State-LSU at Tigers -31.5 and is now at -31.

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